General description
Cell-permeable diacylglycerol analog that activates Ca2+-dependent protein kinase C. Also a stimulator of secretion and aggregation in blood platelets.
Note: 1 set = 10 x 500 µg.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Ca2+-dependent protein kinase C
Product does not compete with ATP.
Reversible: no
Preparation Note
Unstable in solution; reconstitute just prior to use. The material can be dissolved in chloroform, aliquoted, dried under a stream of nitrogen, and stored at -20°C.
Other Notes
Florin-Christensen, J. 1993. Biochem. J.289, 783.
Benz, I., et al. 1992. J. Membr. Biol. 130, 183.
Haeffner, E.W., and Wittmann, U. 1992. J. Lipid Mediat.5, 237.
Gilmore, T., and Martin, G.S. 1983. Nature306, 487.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | oil |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| solubility | DMSO: soluble,ethanol: soluble |
| format | neat |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | O([C@H](COC(=O)CCCCCCC\C=C/CCCCCCCC)CO)C(=O)C |
| InChI | 1S/C23H42O5/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)27-20-22(19-24)28-21(2)25/h10-11,22,24H,3-9,12-20H2,1-2H3/b11-10-/t22-/m0/s1 |
| InChI key | PWTCCMJTPHCGMS-YRBAHSOBSA-N |
