产品介绍
Product Description
Biochem/physiol Actions
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist.
RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to tan |
| solubility | DMSO: ≥20 mg/mL |
| originator | Roche |
| storage temp. | 2-8°C |
| SMILES string | Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23 |
| InChI | 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H |
| InChI key | MKJPYBJBPRFMHL-UHFFFAOYSA-N |
