General description
PANK2 (Pantothenate kinase 2) phosphorylates pantothenic acid (vitamin B(5) and regulates the overall rate of coenzyme A (CoA) biosynthesis. PANK2 thereby plays an important role in lipid metabolism and energy production. Mutation or knockdown of the PANK2 gene results in various disease states, including hypoglycemia, hyperketonemia, faulty metabolism, poor postnatal development, and childhood neurodegeneration.
~62/37 kDa observed. Uncharacterized bands may appear at ~15 kDa, ~25 kDa, and ~260 kDa in some lysates. The calculated molecular weight is 62 kDa, however PANK2 has been shown as a ~40 kDa band in western blots (Kotzbauer, P. T., et al. (2005). The Journal of Neuroscience. 25(3):689-698).
Immunogen
KLH-conjugated linear peptide corresponding to human PANK2.
Application
Detect the PANK2 protein using this Anti-PANK2 validated for use in WB.
Biochem/physiol Actions
This antibody demonstrates specificity for isoform 1, but does not cross react with other isoforms.
Analysis Note
Evaluated by Western Blot in human hippocampus tissue lysate.
Western Blot Analysis: 1.0 µg/mL of this antibody detected PANK2 in 10 µg of human hippocampus tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
| biological source | rabbit |
| Quality Segment | 300 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_705902 |
| UniProt accession no. | Q9BZ23 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PANK2(80025) |
