Clone REA886 recognizes the human CD68 antigen, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/endosomal–associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial cells, and other cells. It is found predominantly in late endosomal and lysosomal compartments, with a modest level of cell surface expression. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism, and extracellular cell-cell and cell-pathogen interactions.
Additional information: Clone REA886 displays negligible binding to Fc receptors.
gp110, Lamp4, SCARD1, macrosialin
Technical specifications
