产品介绍
Product Description
Application
t-TUCB may be used in in vitro studies to examine lipid accumulation and its interaction with omega-3 epoxides in regulating autophagy and endoplasmic reticulum (ER) stress markers.
Biochem/physiol Actions
t-TUCB is an orally active and potent soluble epoxide hydrolase (sEH) inhibitor (h/m/r IC50 = 0.9/1.3/16 nM). t-TUCB modulates inflammation and autophagy in adipose tissue and liver in obese fat-1 mice (10 μg/mL in drinking water, ∼1.67 mg/kg/d). When administered at 10 mg/kg via s.c. t-TUCB is substantially more effective than t-AUCB and APAU in a diabetic neuropathy model in rats.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
