产品介绍
Product Description
Biochem/physiol Actions
Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats.
specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca2+ oscillations
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| web metadata keyword.default | Ned-K (1R,3S)-1-(3-((4-(2-Cyanophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid,Ned-K bioactive small molecule for heart cell studies,Ned-K cardiac protection research grade,Ned-K chemical structure research studies,Ned-K for Ca2+ oscillation suppression in cardiomyocytes,Ned-K for TPC1 channel inhibition studies,Ned-K for cardiomyocyte protection,Ned-K for cardiomyocyte research reagents,Ned-K for research on mitochondrial permeability transition pore,Ned-K inhibitor of NAADP signaling 2250019-90-8,Ned-K nicotinic acid adenine dinucleotide phosphate inhibitor,Ned-K potency and application in ischaemia-reperfusion injury,Ned-K research applications in cardiology,lab-grade Ned-K for cardiomyocyte ischaemia studies |
| storage temp. | −20°C |
