产品介绍
Product Description
Biochem/physiol Actions
(1R,3S)-HPA-12 is a ceramide (Cer) analog that acts as a Cer transporter (CERT) antagonist and selectively inhibits cellular Cer conversion to sphingomyelin (SM), but not to glucosylceramide, by blocking CERT-mediated Cer ER-to-Golgi transport. Common culture dosing range: 1-10 μM.
Ceramide transporter (CERT) antagonist that inhibits Cer-to-sphingomyelin (SM) conversion by blocking CERT-mediated ceramide ER-to-Golgi transport.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | N([C@@H](CO)C[C@H](O)c1ccccc1)C(=O)CCCCCCCCCCC |
| InChI | 1S/C22H37NO3/c1-2-3-4-5-6-7-8-9-13-16-22(26)23-20(18-24)17-21(25)19-14-11-10-12-15-19/h10-12,14-15,20-21,24-25H,2-9,13,16-18H2,1H3,(H,23,26)/t20-,21+/m1/s1 |
| InChI key | YCAKBKAOFSILDC-RTWAWAEBSA-N |
