产品详情

Vernakalant hydrochloride，5MG，SML2938-5MG，Sigma

销售价： ¥ 944.85 / 件

优惠：请询价

订货号： 0BQ1286

品牌型号： SML2938-5MG

货期：询货期

最小订货量： 1件

产品介绍 Product Description

Biochem/physiol Actions

Anti-arrhythmic that exerts anti-fibrillatory efficacy via potential- & rate-dependent Nav1.5 (SCN5A) as well as atrial-selective Kv1.5 (KCNA5) blockade in vivo.
Vernakalant is a multiple ion channel blocker that exerts in vivo anti-fibrillatory (anti-arrhythmic) efficacy (ED₅₀ = 1.5 μmol/kg/min iv. against ischemia-induced arrhythmias in rats) via atrial-selective Kv1.5 blockage (hKv1.5/rKv4.2/rKv4.3 IC₅₀ = 13/38/30 μM at 1Hz & -80 to 60 mV in 200 (Kv1.5) or 400 (Kv4) msec) as well as potential- and rate-dependent Nav1.5 blockade (inward Na current INa IC₅₀ = 9 μM/20 Hz & -80 mV, 31 μM/1Hz & -60 mV, 107 μM/1Hz & -120 mV using HEK hNav1.5 cells).

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
storage condition	desiccated
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	−20°C
SMILES string	Cl.N3(C[C@@H](CC3)O)[C@H]1[C@@H](CCCC1)OCCc2cc(c(cc2)OC)OC
InChI	1S/C20H31NO4.ClH/c1-23-19-8-7-15(13-20(19)24-2)10-12-25-18-6-4-3-5-17(18)21-11-9-16(22)14-21;/h7-8,13,16-18,22H,3-6,9-12,14H2,1-2H3;1H/t16-,17-,18-;/m1./s1
InChI key	JMHYCBFEEFHTMK-IIUXMCBISA-N

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