产品介绍
Product Description
Biochem/physiol Actions
BMS-265246 is an ATP site-targeting, potent and CDK1/2-selective cyclin-dependent kinase inhibitor (IC50 = 6 nM/CDK1, 9 nM/CDK2, 230 nM/CDK4) with anti-cancer efficacy in A2780 ovarian cancer culture (IC50 = 760 nM).
ATP site-targeting, potent and CDK1/CDK2-selective cyclin-dependent kinase inhibitor with anti-cancer efficacy in A2780 ovarian cancer culture.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | FC1=C(C(F)=CC(C)=C1)C(C2=C(C3=C(N=C2)NN=C3)OCCCC)=O |
| InChI | 1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23) |
| InChI key | SCFMWQIQBVZOQR-UHFFFAOYSA-N |
