产品介绍
Product Description
Biochem/physiol Actions
Tipiracil is an inhibitor of thymidine phosphorylase.
Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 5 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | [H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O |
| InChI | 1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H |
| InChI key | KGHYQYACJRXCAT-UHFFFAOYSA-N |
| Gene Information | human ... TYMP(1890) |
