General description
A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5′-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10 µM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300 mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
SHIP2
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ichihara, Y., et al, 2013. Eur. J. Med. Chem.62, 649.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| assay | ≥98% (HPLC) |
| Quality Level | 100 |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 100 mg/mL |
| storage temp. | 2-8°C |
