产品介绍
Product Description
Application
Fumarate hydratase-IN-1 may be used:
- to study its effects on mitochondrial bioenergetics and macrophage metabolism
- to assess its regulatory effects in LPS-induced acute lung injury (ALI) models
- to study the role of fumarate in immunomodulation and regulating type I interferon production after viral infection
Biochem/physiol Actions
FHIN1 exhibits nutrient-dependent antiproliferation activity in cancer cultures (mean IC50 = 2.2 µM in glucose-free L-15 medium; SW620, ACHN, HCT-116, PC3, SK-MEL-28) by targeting tricarboxylic acid (TCA) cycle without blocking mitochondrial electron-transport chain (ETC) or ATP synthase.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
