General description
Zinc transporter ZIP6, also known as Estrogen-regulated protein LIV-1 or Solute carrier family 39 member 6 orZrt- and Irt-like protein 6 (ZIP-6), and encoded by the gene name ZIP6 or SLC39A6 or LIV1 is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP-6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP-6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP-6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP-6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.
~48 and ~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 2 isoforms produced by alternative splicing at ~49 kDa and ~85 kDa
Immunogen
Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human Anti-ZIP-6.
Application
Anti-ZIP-6 Antibody detects level of ZIP-6 & has been published & validated for use in ZIP-6.
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected Anti-ZIP-6 in mouse lung tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Biochem/physiol Actions
This antibody is recognizes isoforms at ~48 and ~85 kDa and is predicted to not cross-react with other ZIP family members.
Physical form
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse lung tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected Anti-ZIP-6 in mouse lung tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| UniProt accession no. | Q13433 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SLC39A6(25800) |
