产品介绍
Product Description
General description
A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
hEGF-R tyrosine kinase activity
Product competes with ATP.
Reversible: no
Target IC50: 54% inhibition at 10 µM against hEGF-R tyrosine kinase activity
Packaging
Packaged under inert gas
Other Notes
Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem.18, 243.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
