产品介绍
Product Description
General description
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Inactive control for Nec-1 (Cat. No. 480065)
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Takahashi et al. 2012. Cell Death and Disease3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | crystalline solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | light yellow |
| solubility | DMSO: 10 mg/mL,methanol: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| InChI | 1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17) |
| InChI key | MPLRRPKKFHUEEL-UHFFFAOYSA-N |
