产品介绍
Product Description
Biochem/physiol Actions
YM-298198 is a selective, noncompetitive mGlu1 receptor antagonist.
YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 5 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Cl.CN(C1CCCCC1)C(=O)c2sc3nc4ccc(N)cc4n3c2C |
| InChI | 1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H |
| InChI key | WYTJVUVCSUWZTH-UHFFFAOYSA-N |
