Application
Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.
Biochem/physiol Actions
Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).
Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.
Features and Benefits
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Preparation Note
Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.
| Quality Level | 100 |
| assay | 99% (HPLC) |
| solubility | DMSO: soluble (at 26 mg/ml),H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+ |
| InChI key | XRZYELWZLNAXGE-KPKJPENVSA-N |
| Gene Information | human ... ERBB2(2064), NTRK1(4914) |
