产品介绍
Product Description
General description
BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.
Application
BL-1249 has been used:
- as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
- as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
- as a TREK1 and TREK2 activator in mice.
Biochem/physiol Actions
BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a potassium TREK-1 channel activator.
BL-1249 is a putative activator of potassium TREK-1 channel.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| storage condition | protect from light |
| color | pink to brown |
| solubility | DMSO: ~17.5 mg/mL,H2O: insoluble |
| storage temp. | −20°C |
| SMILES string | C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4 |
| InChI | 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22) |
| InChI key | YYNRZIFBTOUICE-UHFFFAOYSA-N |
