产品介绍
Product Description
Biochem/physiol Actions
Cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1).
Drp1 inhibitor SC9 is a cell penetrant, potent and selective inhibitor of GTPase activity of dynamin-related protein 1 (Drp1) that binds to a switch I-adjacent grove (SWAG) on Drp1. SC9 inhibits Drp1-Fis1 interaction in cells and eases the burden of Drp1-mediated pathologies such as LPS-induced mitochondrial dysfunction. It rescues mice from LPS-induced endotoxemia.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | CC1=NC2=NC(SCC(N(C(C(N3)=O)=C(N)N(CC4=CC=CC=C4)C3=O)C)=O)=NN2C(C)=C1 |
