产品介绍
Product Description
Biochem/physiol Actions
Hinokiflavone is a plant biflavone that exhibit potent anticancer, hepatoprotective, antibacterial, antiviral, and anti-inflammatory activities. Hinokiflavone induces apoptosis and cell cycle arrest, and blocks migration and invasion of melanoma cells. It is a potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp). Hinokiflavone is a modulator of pre-mRNA splicing in cells. It increases SUMOylation of a subset of spliceosome proteins by inhibiting SENP1 protease activity. It induces apoptosis in esophageal squamous cell carcinoma (ESCC) through regulation of PI3K/AKT/mTOR pathway.
Modulator of pre-mRNA splicing in cells; potent inhibitor of dengue 2 virus RNA-dependent RNA polymerase (DV-NS5 RdRp)
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | [o]1c2c([c](cc1c6ccc(cc6)O)=O)c(c(c(c2)O)Oc3ccc(cc3)c4[o]c5c([c](c4)=O)c(cc(c5)O)O)O |
| InChI | 1S/C30H18O10/c31-16-5-1-14(2-6-16)24-12-21(35)28-26(40-24)13-22(36)30(29(28)37)38-18-7-3-15(4-8-18)23-11-20(34)27-19(33)9-17(32)10-25(27)39-23/h1-13,31-33,36-37H |
| InChI key | WTDHMFBJQJSTMH-UHFFFAOYSA-N |
