产品介绍
Product Description
Application
D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.
Biochem/physiol Actions
D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.
D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | light yellow |
| solubility | DMSO: ~20 mg/mL,H2O: insoluble |
| originator | GlaxoSmithKline |
| storage temp. | 2-8°C |
| SMILES string | NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4 |
| InChI | 1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) |
| InChI key | DPDZHVCKYBCJHW-UHFFFAOYSA-N |
