Application
Torsemide has been used as an inhibitor of Na+ Cl- co-transporter in transgenic Arabidopsis thaliana plants1.
Biochem/physiol Actions
Torsemide functions in the thick ascending limb of the loop of Henle and enhances the excretion of sodium, chloride and water from the luminal side of the cells. Furthermore, torsemide can treat oedematous conditions that are associated with diseases such as liver cirrhosis, kidney disorders and chronic congestive heart failure2.
Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Torsemide is soluble in DMSO at 18 mg/ml and is insoluble in water.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: soluble 18 mg/mL,H2O: insoluble |
| originator | Roche |
| SMILES string | CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 |
| InChI | 1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) |
| InChI key | NGBFQHCMQULJNZ-UHFFFAOYSA-N |
| Gene Information | human ... SLC12A1(6557) |
