Application
MoTP may be used in cell signaling and differentiation studies.
Biochem/physiol Actions
Melanocytotoxic; reversibly blocks the specification of neural crest cells into melanocytes
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥80 mg/mL |
| storage temp. | −20°C |
| SMILES string | Oc1ccc(SCCCCN2CCOCC2)cc1 |
| InChI | 1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2 |
| InChI key | YHKNLUTUXZDOQI-UHFFFAOYSA-N |
