产品介绍
Product Description
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规格 |
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| Accession Number: | NP_004324.1, V599E |
| Assay Entry: | Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic |
| Kinase Group: | Ser⁄Thr Kinases: TKL Group |
| Mass: | 10 µg |
| Protein Form: | Recombinant, Catalytic |
| Research Category: | Oncology, Signal Transduction |
| Shipping Condition: | Dry Ice |
| Species: | Human |
| System Compatibility: | LanthaScreen® Antibody, LanthaScreen® Substrate, Zin-LYTE™ |
| Tag Position: | N-Terminal |
| Target Entry: | BRAF V599E |
| Target Gene: | v-raf murine sarcoma viral oncogene homolog B1 |
| Gene ID (Entrez): | 10488, 673 |
| Molecular Weight: | 67.1 kDa |
| Protein Subtype: | Serine⁄Threonine Kinases |
| Gene Alias: | BRAF V599E |
| Validated Application: | Kinase Assay |
| Protein Family: | Kinases & Inhibitors |
| Expression System: | Baculovirus |
| KinaseFamily: | RAF Kinase Family |
| Protein Length: | aa 416-766 |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
BRAF acts upstream of MEK in the MAP kinase pathway and is involved in cell division, differentiation, and secretion. The BRAF mutant V599E is oncogenic and found in a variety of cancers.
