产品介绍
Product Description
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规格 |
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| Assay Entry: | Biochemical binding/kinetic |
| Kinase Group: | Serine/Threonine Kinase |
| Species: | Human |
| Target Entry: | LATS2 |
| Molecular Weight: | 95.6 kDa |
| Gene Alias: | LATS2, KPM |
| Validated Application: | Kinase Assay |
| Protein Length: | aa 480-1088 |
| Protein Tag: | GST Tag |
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储存 |
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Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
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描述 |
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction. LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity. Recombinant human LATS2 (480-1088) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
• Validated in LanthaScreen® Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use
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LanthaScreen® Eu Kinase Binding Assay
