General description
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Biochem/physiol Actions
Cell permeable: no
Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no
Other Notes
Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | white |
| solubility | 1 N acetic acid: 5 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
