General description
一种细胞可渗透、不可逆的泛半胱天冬酶抑制剂。显示可提高人类胚胎干细胞的冻融存活率。抑制Jurkat T细胞中Fas介导的细胞凋亡。据报道，它也抑制肽：体外和体内的N-聚糖酶 (PNGase)。当与纯化的重组酶一起使用时，需要用酯酶进行预处理。
Biochem/physiol Actions
主靶
Fas介导的Jurkat细胞凋亡和星形孢菌素诱导的角膜上皮细胞死亡
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液可在-20°C稳定6个月。
Analysis Note
TLC 单点
Other Notes
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Zhu, H., et al. 1995.FEBS Lett.374, 303.
Z-Val-Ala-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
| Quality Level | 100 |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated |
| color | white |
| solubility | DMSO: 50 mM |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC |
| InChI | 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1 |
| InChI key | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
