General description
A cell-permeable and potent inducer of VEGF and VEGF-mediated blood vessel formation. GS4012-induced upregulation of VEGF correlates with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs. An essential molecule required during angioblasts cell fate determination.
A cell-permeable pyridinyl-thioether compound that acts as a potent inducer of VEGF and VEGF-mediated vessel formation. GS4012-induced upregulation of VEGF correlates well with its ability to suppress the gridlock/coarctation phenotype (7.5 µg/ml) in Zebrafish and to stimulate tubule network formation (5 µg/ml) in HUVECs.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Potent inducer of VEGF and VEGF-mediated vessel formation
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Peterson, R.T., et al. 2004. Nat. Biotechnol.22, 595.
Depre, C., et al. 2003. Circulation108, 2723.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | white |
| solubility | DMSO: 200 mg/mL,methanol: 50 mg/mL,water: soluble |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | S(CCc2ccncc2)c1ccc(cc1)OC.Cl |
| InChI | 1S/C14H15NOS.ClH/c1-16-13-2-4-14(5-3-13)17-11-8-12-6-9-15-10-7-12;/h2-7,9-10H,8,11H2,1H3;1H |
| InChI key | CYZALCLQLHDAEC-UHFFFAOYSA-N |
