General description
Product Source: N-terminal GST-tagged, recombinant, full length, human PP5, expressed in E. coli cells.
This protein is a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family.
Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine
residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of
this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants.
Packaging
Also available in 250μg size as catalog # 14-778M and in bulk as catalog # 14-778-K.
Physical form
Purified using glutathione agarose.
Analysis Note
Routinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP)
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| Quality Segment | 100 |
| mol wt | Mw 83.8 kDa |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (phosphatase) |
| NCBI accession no. | NM_006247 |
| Gene Information | human ... PPP5C(5536) |
