General description
70 kDa
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Immunogen
Epitope: Center region
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter.
Application
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
This Anti-Serotonin Transporter Antibody is validated for use in WB for the detection of Serotonin Transporter.
Biochem/physiol Actions
Other species have not been tested.
The antibody reacts with the 70 kDa serotonin transporter protein.
Physical form
Antigen Affinity Purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Preparation Note
Store at 2-8°C for 1 year from date of receipt.
Analysis Note
Control
Western Blot : Human lung lysate.
Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate.
Other Notes
Replaces: AB1594P
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity (predicted by homology) | sheep (100% homology), rat (100% homology), bovine (100% homology), monkey (100% homology), human (100% homology), horse (100% homology), mouse (100% homology), chimpanzee (100% homology) |
| concentration | 1 mg/mL |
| technique(s) | western blot: suitable |
| UniProt accession no. | P31645 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... HTT(3064) |
