产品介绍
Product Description
General description
一种细胞可渗透性、可逆和ATP竞争性的蛋白激酶C（PKC；大鼠脑的IC50=7.9 nM）抑制剂。选择性抑制Ca2+依赖性PKCα-同工酶（IC50=2.3 nM）和PKCβI（IC50=6.2 nM）。即使在微摩尔水平下，也不会影响不依赖Ca2+的PKCδ-，ε-和ζ-同工酶的激酶活性。据报道，在较高浓度（IC50=20 nM）下可抑制PKCµ。也可获得500 µg/mL的Gö 6976（目录编号365253）在无水DMSO中的溶液。
Biochem/physiol Actions
主要靶标
PKC
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：7.9 nM，针对大鼠脑PKC；针对Ca2+依赖性PKCα-同工酶和PKCβI分别为2.3 nM和6.2 nM
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定4个月。
Other Notes
Gschwendt, M., et al. 1996.FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994.Biochem.Biophys.Res. Commun.200, 1536.
Martiny-Baron, G.M., et al. 1993.J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993.Proc.Natl.Acad.Sci. USA90, 4674.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | off-white |
| solubility | DMSO: 5 mg/mL |
| web metadata keyword.default | Go 6976 cell-permeable inhibitor,Gö 6976 500 µg/ml solution in DMSO,Gö 6976 ATP-competitive inhibitor,Gö 6976 CAS 136194-77-9,Gö 6976 Ca2+ dependent PKC inhibitor,Gö 6976 PKC alpha isozyme inhibitor,Gö 6976 chemical structure and applications,Gö 6976 for cell signaling studies,Gö 6976 for cellular signal transduction research,Gö 6976 high purity research reagent,Gö 6976 kinase activity assay reagent,Gö 6976 procurement,Gö 6976 protein kinase C inhibitor,Gö 6976 reversible protein kinase inhibitor,lab-grade Gö 6976 for research |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [n]1(c2c3[n](c4c(c3c5c(c2c6c1cccc6)CNC5=O)cccc4)C)CCC#N |
| InChI | 1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) |
| InChI key | VWVYILCFSYNJHF-UHFFFAOYSA-N |
