产品介绍
Product Description
General description
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
Packaging
Packaged under inert gas
Other Notes
Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | semisolid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | pale yellow |
| solubility | DMSO: 100 mg/mL, clear, colorless |
| shipped in | wet ice |
| storage temp. | −20°C |
| SMILES string | COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1 |
| InChI key | JEXHQZPMUKFOIV-SSDVNMTOSA-N |
