产品介绍
Product Description
Biochem/physiol Actions
NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).
Packaging
Packaged under nitrogen.
Analysis Note
IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | white to off-white |
| mp | 88.2-94.9 °C |
| solubility | DMSO: >20 mg/mL |
| storage temp. | −20°C |
| SMILES string | [I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C |
| InChI | 1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1 |
| InChI key | RVWOHCBHAGBLLT-UHFFFAOYSA-M |
