产品介绍
Product Description
Biochem/physiol Actions
CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
Wnt β-catenin antagonist
技术参数
Specifications
| assay | ≥98% (HPLC) |
| Quality Segment | 100 |
| form | powder |
| color | white to tan |
| solubility | DMSO: ≥20 mg/mL (warm to 60°C) |
| storage temp. | −20°C |
| SMILES string | Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4 |
| InChI | 1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25) |
| InChI key | IFOHRIXRQPOHQZ-UHFFFAOYSA-N |
