General description
Research area: Neuroscience
Glycine is a simple non-essential amino acidIt is synthesized from choline, threonine and serine. It serves as a precursor for porphyrins, purines, glutathione and creatine.
Application
Glycine sodium salt hydrate has been used as a component of buffer for homogenization of whole muscle for protein extraction and in electrophoresis buffer. It has also been used as a neurotransmitter in immunohistochemical staining of Zebrafish spinal cord sections.
Biochem/physiol Actions
Glycine serves as a neurotransmitter in the central nervous system. It aids in increasing the quality of sleep and neurological functions. It is essential for the regulation immune function, metabolism, growth and development. Glycine modulates intracellular Ca2+ levels and cytokines production. Studies have shown that glycine treatment effectively prevents organ transplantation failure by mitigating ischemia reperfusion injury caused by cold ischemic storage. Additionally, glycine treatment also enhances graft function during transplantation. A reduction in glycine levels is observed in obesity, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLDs). Glycine is degraded to serine by glycine serine hydroxymethyltransferase 1 in cytoplasm.
| biological source | synthetic (organic) |
| Quality Level | 300 |
| assay | ≥99% (HPLC) |
| form | powder |
| mol wt | 97.05 g/mol (anhydrous basis) |
| technique(s) | electrophoresis: suitable |
| mp | 197-201 °C (lit.) |
| SMILES string | [Na+].[H]O[H].NCC([O-])=O |
| InChI | 1S/C2H5NO2.Na.H2O/c3-1-2(4)5;;/h1,3H2,(H,4,5);;1H2/q;+1;/p-1 |
| InChI key | CIJQGPVMMRXSQW-UHFFFAOYSA-M |
