Pritelivir，50MG，SML3422-50MG，Sigma

Biochem/physiol Actions

Potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor with antiviral efficacy in cultures and in mice in vivo.
Pritelivir (AIC316; BAY57-1293) is a potent and orally active herpes simplex virus (HSV) helicase-primase inhibitor (IC50 = 30 nM using wt HSV-1F ATPase complex UL5-UL52 & 1 mM ATP) with antiviral efficacy in Vero cultures (replication IC50 = 20 nM against HSV-2G, wt and Acyclovir-resistant HSV-1F; MOI = 0.0025) and in mice in vivo (ED50 = 0.5 mg/kg 3x daily p.o. using HSV-1 Walki or HSV-2 MS), being >28 times more potent than acyclovir and valacyclovir.