产品介绍
Product Description
Application
X80 has been used as an inhibitor of nucleotide excision repair (NER) pathway to study its effects on 8-hydroxy-2′-deoxyguanosine (8-OHdG) excision in the zygote post-fertilization.
Biochem/physiol Actions
X80 is a XPA protein inhibitor.
X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | orange |
| solubility | DMSO: >40 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | CC1=NN(c2cccc(c2)C(O)=O)C(=O)\C1=C/c3ccc(o3)-c4ccc(Cl)c(c4)C(O)=O |
| InChI | 1S/C23H15ClN2O6/c1-12-17(21(27)26(25-12)15-4-2-3-14(9-15)22(28)29)11-16-6-8-20(32-16)13-5-7-19(24)18(10-13)23(30)31/h2-11H,1H3,(H,28,29)(H,30,31)/b17-11- |
| InChI key | XZRBYOCWWJMJRZ-BOPFTXTBSA-N |
