General description
Runt-related transcription factor 1 (RUNX1) is a transcription factor that plays a crucial role in hematopoiesis, osteogenesis and neurogenesis. It is a member of Runt-related transcription factors (RUNXs). It was first identified as a component of Polyomavirus enhancer binding protein 2 (PEBP2) and Moloney murine leukemia virus enhancer core binding factor (CBF). Three isoforms of the protein have been identified: RUNX1a, RUNX1b and RUNX1c.
Application
RUNX1 antibody was raised against a 16 amino acid peptide from near the center of human RUNX1.
Biochem/physiol Actions
RUNX1 (Runt-related transcription factor 1) plays a vital role in tumour suppression and oncogenic activities.[1] In hematopoiesis, it is involved in hematopoietic development, hematopoietic stem cell homeostasis, and various blood malignancies. It may have clinicopathological impact on the proliferation of human bone marrow cells used in transplantation therapy.[3]
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500417.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | indirect ELISA: suitable,western blot: suitable |
| NCBI accession no. | AAI36381 |
| UniProt accession no. | Q01196 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... RUNX1(861) |
