产品详情

FT895，25MG，SML2926-25MG，Sigma

销售价： ¥ 4092.61 / 件

优惠：请询价

订货号： 0BU6255

品牌型号： SML2926-25MG

货期：询货期

最小订货量： 1件

产品介绍 Product Description

Biochem/physiol Actions

FT895 is a potent and highly selective HDAC11 inhibitor (IC₅₀ = 3 nM/HDAC11, 5.6 μM/HDAC8, >10 μM/HDAC1-7, HDAC9 & HDAC10) with a deacetylase active site Zn²⁺-targeting hydroxamate. FT895 exhibits antiproliferation potency against myeloproliferative neoplasm (MPN) cultures (IC₅₀ = 3.00 μM/JAK2(V617F) Ba/F3, 4.94 μM/HEL92.1.7, 6.49 μM/MPL(W515L) Ba/F3) and reduces stem-like properties of CSCs (42/62/85/100% inhibtion of H1650 Sphere formation at 0.5/1/2/5 μM).
Potent and highly selective HDAC11 inhibitor that reduces myeloproliferative neoplasm (MPN) proliferation and CSCs stem-like properties.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 2 mg/mL, clear
storage temp.	2-8°C
SMILES string	FC(F)(F)c1ncc(nc1)N2C(c3c(c(ccc3)C(=O)NO)C2)(C)C
InChI key	XCLPBILTRRWOIL-UHFFFAOYSA-N

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