产品介绍
Product Description
Application
SB-590885 has been used as a component of a mixture to maintain naive human pluripotent stem cells (PSCs).It has also been used as B-Raf (BRAF) inhibitor to study its effects on lung adenocarcinoma cell lines.
Biochem/physiol Actions
SB-590885 is a potent and selective ATP competitive inhibitor of B-Raf kinase with Kd = 300 pM for B-Raf, and >1000-fold selectivity over a panel of 22 commonly studied cellular kinases
SB-590885 is a potent and selective B-Raf kinase inhibitor.
Features and Benefits
This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL (clear solution, warmed) |
| storage temp. | 2-8°C |
| SMILES string | CN(C)CCOc1ccc(cc1)-c2nc(-c3ccc4c(CC\C4=N\O)c3)c([nH]2)-c5ccncc5 |
| InChI | 1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24- |
| InChI key | MLSAQOINCGAULQ-QLTSDVKISA-N |
