产品介绍
Product Description
Biochem/physiol Actions
BAF312 (Siponimod) is an orally active, potent and subtype-selective sphingosine-1-phosphate (S1P) receptor agonist (GTPγ binding EC50 = 0.39 nM/S1P1, 0.98 nM/S1P5, 750 nM/S1P4, >1 µM/S1P3, >10 µM/S1P2). BAF312 oral administration causes a dose-dependent decrease in peripheral lymphocyte counts (by 88% 8h post 1 mg/kg, by 50% 6h post 0.14 mg/kg).
Orally active, potent and subtype-selective sphingosine-1-phosphate (S1P) receptor S1P1 & S1P5 agonist.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | FC(F)(F)c1c(ccc(c1)CONC(=C)c3cc(c(cc3)CN4CC(C4)C(=O)O)CC)C2CCCCC2 |
| InChI | 1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30,31)32/h9-14,22,25,33H,2-8,15-18H2,1H3,(H,35,36) |
| InChI key | VVEHSNDBXFCTMJ-UHFFFAOYSA-N |
