产品介绍
Product Description
Application
N-Acetylprocainamide hydrochloride may be used:
- as an internal standard for spiking plasma samples for ultra-high-pressure liquid chromatography coupled with a diode array detector (UHPLC-DAD) analysis
- to test its relaxant effect on tracheal smooth muscle tissue preparations
- in preparation of complexes with N-acetyl-
L -tyrosine methyl ester and N-acetyl-L -phenylalanine methyl ester for studying intermolecular interactions using nuclear magnetic resonance (NMR) spectroscopy studies
N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。
作用于钾电流的 III 类抗心律失常药。
N-acetyltransferase II in liver catalyzes the conversion of procainamide to N-acetylprocainamide (NAPA).
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥99% (HPLC) |
| form | powder |
| mp | 184-186 °C (lit.) |
| solubility | H2O: 50 mg/mL |
| storage temp. | −20°C |
| SMILES string | Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1 |
| InChI | 1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H |
| InChI key | IYEWBJUCJHKLHD-UHFFFAOYSA-N |
