产品介绍
Product Description
Application
Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).
Biochem/physiol Actions
Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥97% (NMR) |
| form | solid |
| color | white |
| mp | >300 °C |
| solubility | H2O: ≥10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O |
| InChI | 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2 |
| InChI key | GWBBVOVXJZATQQ-UHFFFAOYSA-L |
