Immunogen
purified, E. coli-derived, recombinant mouse RANTES.
Biochem/physiol Actions
RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 53405.111, monoclonal |
| form | lyophilized powder |
| purified by | using protein G |
| species reactivity | mouse |
| technique(s) | immunocytochemistry: 8-25 μg/mL using mouse splenocytes,neutralization: suitable |
| isotype | IgG2a |
| UniProt accession no. | P30882 |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Ccl5(20304) |
