产品详情

两性霉素B 来源于链霉菌 属，250MG，A2411-250MG，Sigma

销售价： ¥ 1640.93 / 件
优    惠： 请询价
订货号 ： 0BS1472
品牌型号 ： A2411-250MG
货期 ： 询货期
最小订货量 ： 1件
产品介绍 Product Description

General description

Chemical structure: polyene


Application

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.


Biochem/physiol Actions

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。


Preparation Note

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.


Other Notes

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture.


Disclaimer

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.


技术参数 Specifications
biological sourceStreptomyces sp.
Quality Segment300
product lineBioReagent
assay~80% (HPLC)
formsolid
potency>750.00 μg per mg (Dry basis)
technique(s)cell culture | mammalian: suitable
color yellow to yellow-orange
solubilityH2O: slightly soluble
antibiotic activity spectrumfungi,yeast
mode of actioncell membrane | interferes
storage temp.2-8°C
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InChI keyAPKFDSVGJQXUKY-INPOYWNPSA-N
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