产品介绍
Product Description
Biochem/physiol Actions
SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and in mouse models.
cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models.
技术参数
Specifications
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | [S](=O)(=O)(c2nn[n](c2C)c3c(ccc(c3)OC)OC)c1ccc(cc1)C(C)(C)C |
| InChI key | OIOPHIFJQXHPAF-UHFFFAOYSA-N |
