产品介绍
Product Description
Application
SMER3 may be used in cell signaling studies.
Biochem/physiol Actions
Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | yellow |
| solubility | DMSO: ≥30 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | O=C1c2ccccc2-c3nc4nonc4nc13 |
| InChI | 1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H |
| InChI key | SFSSAKVWCKFRHE-UHFFFAOYSA-N |
