General description
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Human Osteoblasts-Rheumatoid Arthritis, HOb-RA, are isolated from bone of patients with rheumatoid arthritis (RA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.Characterization: Positive for bone mineralization.
Application
model system to study the pathophisiology of rheumatoid arthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism
Biochem/physiol Actions
Bone
Preparation Note
- 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
- Can be cultured at least 10 doublings
Please refer to the HOb-RA Culture Protocol.
Other Notes
Basal Medium containing 10% FBS & 10% DMSO
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
| biological source | human bone (rheumatoid arthritic) |
| Quality Segment | 100 |
| packaging | pkg of 500,000 cells |
| manufacturer/tradename | Cell Applications, Inc |
| growth mode | Adherent |
| karyotype | 2n = 46 |
| morphology | osteoblast |
| technique(s) | cell culture | mammalian: suitable |
| relevant disease(s) | arthritis |
| shipped in | dry ice |
| storage temp. | −196°C |
