Application
TH-Z145 may be used as a research tool in studies investigating the mevalonate pathway and its implications in various biological processes, including cancer and inflammation. It may also be used as a potent vaccine adjuvant to enhance immune responses by targeting the mevalonate pathway to improve the efficacy of vaccines.
Biochem/physiol Actions
Potent and selective mevalonate (MVA) pathway geranylgeranyl diphosphate synthase (GGPPS) inhibitor that stimulates immune responses in vivo.
TH-Z145 is a potent and selective geranylgeranyl diphosphate synthase (GGPPS) inhibitor (IC50 = 210 nM; FPPS IC50 > 30 µM) that stimulates immune responses by blocking the mevalonate (MVA) pathway-mediated post-translational protein geranylgeranylation. When co-administered with antigen in mice in vivo, TH-Z145 triggers strong adjuvant responses, increasing OVA-specific antibody titres (in mice immunized with 100 μg OVA + 100 μg TH-Z145) and protecting against death caused by live influenza virus PR8 challenge (in mice immunized with 5 μg PR8 HA1 subunit containing TH-Z145). TH-Z145 adjuvant efficacy is blocked by GGPP and synergized with HMG-CoA inhibitor simvastatin.
| Quality Segment | 100 |
| assay | ≥90% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=P(O)(C(P(O)(O)=O)CC1=CC(OCCCCCCCC)=CC=C1)O |
