产品介绍
Product Description
Application
Phenoxodiol may be used to study immunomodulatory effects on human peripheral blood mononuclear cells in in vitro and in vivo assays.
Biochem/physiol Actions
Phenoxodiol, an isoflavene, is a broad-spectrum anti-tumor agent that causes apoptosis via both intrinsic and extrinsic pathways. It is a pan-cancer drug that targets plasma membrane electron transport (PMET). It also acts as a potent sensitizer of most standard chemotoxic agents. Phenoxodiol inhibits tumor-specific NADH oxidase tNOX (ENOX2) and DNA topoisomerase II. It blocks phosphorylation and activation of several different pro-survival signaling proteins including sphingosine kinase and Akt. It is also known to inhibit tyrosine kinases and X-linked inhibitor of apoptosis.
技术参数
Specifications
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to pink |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
